Geodorum densiflorum, Diospyros blancoi, Baccaurea ramiflora and Trichosanthes dioica are four important medicinal plants used traditionally in various diseases. Different parts of these plants have been used in different painful conditions. Therefore, the present study was designed to investigate the analgesic activities of methanol extract of pseudobulb of G. densiflorum, seeds of D. blancoi, Seeds of B. ramiflora and aerial parts of T. dioica using acetic acid-induced writhing and tail immersion test. The results demonstrated that aerial parts of T. dioica and seeds of B. ramiflora possess significant analgesic activity in both acetic acid-induced writhing as well as in tail immersion test. Pseudobulb of G. densiflorum and seeds of D. blancoi also possess moderate analgesic activity.