The paper presents the selection of the best anti-armor missile system, as a significant weapon whose basic task is to neutralize tanks, armored combat and non-combat vehicles at different firing distances. The complexity of the problem is conditioned by the different tactical and technical characteristics of anti-tank missile systems and the specific conditions of their application have conditioned the application of the model of multi-criteria decision-making. The selection of the most favorable anti-armor missile system was realized using the hybrid model AHP-VIKOR. Using the AHP method, the values of the criterion coefficients were calculated. The VIKOR method was used to select the most favorable alternative (anti-armor missile system). Based on the obtained results, a set of compromise solutions was defined, on the basis of which the decision maker can decide on the selection of the best anti-armor missile system.