Cutaneous squamous cell carcinoma is the second most prevalent malignancy, most
frequently occurring in the head and neck (head and neck cutaneous squamous cell
carcinoma). Treatment of locally advanced or metastatic disease is associated with
functional morbidity and disfigurement. Underlying genetic mechanisms are poorly
understood. Targeted sequencing of 48 clinically relevant genes was performed on DNA
extracted from formalin-fixed and paraffin-embedded high-risk primary head and neck …