[HTML][HTML] Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation
Journal of neuroscience methods, 2016•Elsevier
Abstract Background Deep Brain Stimulation (DBS) is an effective treatment for several
neurological and psychiatric disorders. In order to gain insights into the therapeutic
mechanisms of DBS and to advance future therapies a better understanding of the effects of
DBS on large-scale brain networks is required. New method In this paper, we describe an
experimental protocol and analysis pipeline for simultaneously performing DBS and
intracranial local field potential (LFP) recordings at a target brain region during concurrent …
neurological and psychiatric disorders. In order to gain insights into the therapeutic
mechanisms of DBS and to advance future therapies a better understanding of the effects of
DBS on large-scale brain networks is required. New method In this paper, we describe an
experimental protocol and analysis pipeline for simultaneously performing DBS and
intracranial local field potential (LFP) recordings at a target brain region during concurrent …
Background
Deep Brain Stimulation (DBS) is an effective treatment for several neurological and psychiatric disorders. In order to gain insights into the therapeutic mechanisms of DBS and to advance future therapies a better understanding of the effects of DBS on large-scale brain networks is required.
New method
In this paper, we describe an experimental protocol and analysis pipeline for simultaneously performing DBS and intracranial local field potential (LFP) recordings at a target brain region during concurrent magnetoencephalography (MEG) measurement. Firstly we describe a phantom setup that allowed us to precisely characterise the MEG artefacts that occurred during DBS at clinical settings.
Results
Using the phantom recordings we demonstrate that with MEG beamforming it is possible to recover oscillatory activity synchronised to a reference channel, despite the presence of high amplitude artefacts evoked by DBS. Finally, we highlight the applicability of these methods by illustrating in a single patient with Parkinson's disease (PD), that changes in cortical-subthalamic nucleus coupling can be induced by DBS.
Comparison with existing approaches
To our knowledge this paper provides the first technical description of a recording and analysis pipeline for combining simultaneous cortical recordings using MEG, with intracranial LFP recordings of a target brain nucleus during DBS.
Elsevier
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