[PDF][PDF] Analysis of the Molecular Networks in Androgen Dependent and Independent Prostate Cancer
Androgen ablation therapy is currently the primary treatment for metastatic prostate cancer.
Unfortunately, in nearly all cases, androgen ablation fails to permanently arrest cancer
progression. As androgens like testosterone are withdrawn, prostate cancer cells lose their
androgen sensitivity and begin to proliferate without hormone growth factors. In this study,
we constructed and analyzed a mathematical model of the integration between hormone
growth factor signaling, androgen receptor activation, and the expression of cyclin D and …
Unfortunately, in nearly all cases, androgen ablation fails to permanently arrest cancer
progression. As androgens like testosterone are withdrawn, prostate cancer cells lose their
androgen sensitivity and begin to proliferate without hormone growth factors. In this study,
we constructed and analyzed a mathematical model of the integration between hormone
growth factor signaling, androgen receptor activation, and the expression of cyclin D and …
Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems
Androgen ablation therapy is currently the primary treatment for metastatic prostate cancer.
Unfortunately, in nearly all cases, androgen ablation fails to permanently arrest cancer
progression. As androgens like testosterone are withdrawn, prostate cancer cells lose their
androgen sensitivity and begin to proliferate without hormone growth factors. In this study,
we constructed and analyzed a mathematical model of the integration between hormone
growth factor signaling, androgen receptor activation, and the expression of cyclin D and …
Unfortunately, in nearly all cases, androgen ablation fails to permanently arrest cancer
progression. As androgens like testosterone are withdrawn, prostate cancer cells lose their
androgen sensitivity and begin to proliferate without hormone growth factors. In this study,
we constructed and analyzed a mathematical model of the integration between hormone
growth factor signaling, androgen receptor activation, and the expression of cyclin D and …
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