Animal models of aging research: implications for human aging and age-related diseases

SJ Mitchell, M Scheibye-Knudsen… - Annu. Rev. Anim …, 2015 - annualreviews.org
Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human
diseases, and understanding the aging process may thereby facilitate the development of
new treatments for age-associated diseases. The use of humans in aging research is
complicated by many factors, including ethical issues; environmental and social factors; and
perhaps most importantly, their long natural life span. Although cellular models of human …
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