Cancer-associated hypercalcemia (CAH) is a frequently-occurring paraneoplastic syndrome
that contributes to substantial patient morbidity and occurs in both humans and animals.
Patients with CAH are often characterized by markedly elevated serum calcium
concentrations that result in a range of clinical symptoms involving the nervous,
gastrointestinal and urinary systems. CAH is caused by two principle mechanisms;
humorally-mediated and/or through local osteolytic bone metastasis resulting in excessive …

Athymic or nude (nu/nu) mice Mice lack T lymphocytes CAH Cancer-associated
hypercalcemia HHM Humoral hypercalcemia of malignancy NOD mice Nonobese diabetic
mice lack B lymphocytes NOD/SCID mice Mice lack T and B lymphocytes NSG mice NOD
SCID gamma mice lack T and B lymphocytes and natural killer cells PTHrP Parathyroid
hormone-related protein SCID mice Severe combined immunodeficient mice lack T
lymphocytes SCID/beige mice Lack T lymphocytes and impaired NK cell function