Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB

SZ Moghadamtousi, HA Kadir, M Paydar… - … and alternative medicine, 2014 - Springer
Background Annona muricata leaves have been reported to have antiproliferative effects
against various cancer cell lines. However, the detailed mechanism has yet to be defined.
The current study was designed to evaluate the molecular mechanisms of A. muricata
leaves ethyl acetate extract (AMEAE) against lung cancer A549 cells. Methods The effect of
AMEAE on cell proliferation of different cell lines was analyzed by MTT assay. High content
screening (HCS) was applied to investigate the suppression of NF-κB translocation, cell …

Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB.

SZM Soheil Zorofchian Moghadamtousi… - 2014 - cabidigitallibrary.org
Background: Annona muricata leaves have been reported to have antiproliferative effects
against various cancer cell lines. However, the detailed mechanism has yet to be defined.
The current study was designed to evaluate the molecular mechanisms of A. muricata
leaves ethyl acetate extract (AMEAE) against lung cancer A549 cells. Methods: The effect of
AMEAE on cell proliferation of different cell lines was analyzed by MTT assay. High content
screening (HCS) was applied to investigate the suppression of NF-κB translocation, cell …
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