Anti‐proliferative and anti‐malarial activities of spiroisoxazoline analogues of artemisinin
A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1, 3‐
dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All
the synthesized compounds were tested for their anti‐proliferative and anti‐malarial
activities. Among the compounds tested, compound 11a was found to be potent against the
HCT‐15 cancer cell line with IC50= 4.04 μM when compared to 5‐fluorouracil (IC50= 35.53
μM). DNA cell cycle analysis shows that 11a was inhibiting cell proliferation at the G2/M …
dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All
the synthesized compounds were tested for their anti‐proliferative and anti‐malarial
activities. Among the compounds tested, compound 11a was found to be potent against the
HCT‐15 cancer cell line with IC50= 4.04 μM when compared to 5‐fluorouracil (IC50= 35.53
μM). DNA cell cycle analysis shows that 11a was inhibiting cell proliferation at the G2/M …
Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin.
SP Surya Pratap, FN Fatima Naaz, SR Srinivas Reddy… - 2019 - cabidigitallibrary.org
A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1, 3-
dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All
the synthesized compounds were tested for their anti-proliferative and anti-malarial
activities. Among the compounds tested, compound 11a was found to be potent against the
HCT-15 cancer cell line with IC50= 4.04 µM when compared to 5-fluorouracil (IC50= 35.53
µM). DNA cell cycle analysis shows that 11a was inhibiting cell proliferation at the G2/M …
dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All
the synthesized compounds were tested for their anti-proliferative and anti-malarial
activities. Among the compounds tested, compound 11a was found to be potent against the
HCT-15 cancer cell line with IC50= 4.04 µM when compared to 5-fluorouracil (IC50= 35.53
µM). DNA cell cycle analysis shows that 11a was inhibiting cell proliferation at the G2/M …
以上显示的是最相近的搜索结果。 查看全部搜索结果