Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence
SA El-Marasy, SA El Awdan, A Hassan… - Chemico-biological …, 2021 - Elsevier
Depression is a major psychological disorder that contributes to global health problem. This
study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-
induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-
dependent response element binding protein (CREB)/brain derived neurotropic factor
(BDNF) signaling pathways, brain monoamines and histopathological changes was
assessed. Rats received either the vehicle or Reserpine (0.5 mg/kg, ip) for 14 days. The …
study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-
induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-
dependent response element binding protein (CREB)/brain derived neurotropic factor
(BDNF) signaling pathways, brain monoamines and histopathological changes was
assessed. Rats received either the vehicle or Reserpine (0.5 mg/kg, ip) for 14 days. The …
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