Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors
Some synthesized antitumor derivatives of thiazole based chalcones including thiazolo [2, 3-
b] quinazoline and pyrido [4, 3-d] thiazolo [3, 2-a] pyrimidine analogues were subjected to
be tested against standard microbial strains. Compound 18 showed higher activity against
both Gram-positive and Gram-negative bacteria with MIC of 1.0, 1.0, 2.0, 2.0 and 4.0 μg/ml
against S. aureus, B. subtilis, M. luteus, E. coli and P. aeuroginosa respectively which is
better than ampicillin and very relative to ciprofloxacin standards. Moreover, this compound …
b] quinazoline and pyrido [4, 3-d] thiazolo [3, 2-a] pyrimidine analogues were subjected to
be tested against standard microbial strains. Compound 18 showed higher activity against
both Gram-positive and Gram-negative bacteria with MIC of 1.0, 1.0, 2.0, 2.0 and 4.0 μg/ml
against S. aureus, B. subtilis, M. luteus, E. coli and P. aeuroginosa respectively which is
better than ampicillin and very relative to ciprofloxacin standards. Moreover, this compound …
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