Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative bacteria in biofilms
JS Novais, CS Moreira, ACJA Silva, RS Loureiro… - Microbial …, 2018 - Elsevier
The aims of this study were the planning, synthesis and in vitro evaluation of 2-hydroxy-3-
phenylsulfanylmethyl-[1, 4]-naphthoquinones against Gram-negative and Gram-positive
strains, searching for potential lead compounds against bacterial biofilm formation. A series
of 12 new analogs of 2-hydroxy-3-phenylsulfanylmethyl-[1, 4]-naphthoquinones were
synthesized by adding a thiol and different substituents to a ο-quinone methide using
microwave irradiation. The compounds were tested against Gram-positive (Enterococcus …
phenylsulfanylmethyl-[1, 4]-naphthoquinones against Gram-negative and Gram-positive
strains, searching for potential lead compounds against bacterial biofilm formation. A series
of 12 new analogs of 2-hydroxy-3-phenylsulfanylmethyl-[1, 4]-naphthoquinones were
synthesized by adding a thiol and different substituents to a ο-quinone methide using
microwave irradiation. The compounds were tested against Gram-positive (Enterococcus …
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