Most bacteria in nature exist in aggregated communities known as biofilms. Bacteria within
biofilms are inherently highly resistant to antibiotics. Current understanding of the evolution
and mechanisms of antibiotic resistance is largely derived from work from cells in liquid
culture and it is unclear whether biofilms adapt and evolve in response to sub-inhibitory
concentrations of drugs. Here we used a biofilm evolution model to show that biofilms of a
model food borne pathogen, Salmonella Typhimurium rapidly evolve in response to …