[HTML][HTML] Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals
The Lancet, 2021•thelancet.com
… We reasoned that previous infection could be analogous to immune priming. As such, a first
prime vaccine dose would effectively act as boost, so a second dose might not be needed. To
test this, we undertook a nested case-control analysis of 51 participants of COVIDsortium, …
These serological data suggest that for individuals receiving the BNT162b2 mRNA vaccine, a
potential approach is to include serology testing at or before the time of first vaccination to
prioritise use of booster doses for individuals with no previous infection. This could potentially …
prime vaccine dose would effectively act as boost, so a second dose might not be needed. To
test this, we undertook a nested case-control analysis of 51 participants of COVIDsortium, …
These serological data suggest that for individuals receiving the BNT162b2 mRNA vaccine, a
potential approach is to include serology testing at or before the time of first vaccination to
prioritise use of booster doses for individuals with no previous infection. This could potentially …
Most vaccine platforms use a two-dose prime-boost approach to generate an immune response against the virus S1 spike protein, the titres of which correlate with functional virus neutralisation and increase with boosting.
thelancet.com