The use of estrogenic compounds as antidepressants or as coadjuvants to facilitate the
effect of antidepressants has reported controversial results, suggesting that many factors
could influence their actions. This review analyzes, from a basic research perspective, the
possible factors that may underlie the antidepressant action of estrogens alone or in
combination. The possible mechanisms of action of estrogens alone and in combination with
the selective serotonin reuptake inhibitor, fluoxetine, the selective noradrenaline reuptake …