This study investigated the antidepressant like effect of chloroform and ethanol extract of Sargassum ilicifolium, A brown algae in mouse forced swimming test (FST) and tail suspension test (TST). The locomotor activity was tested, using Actophotometer to detect any association of immobility in the FST and TST with changes in motor activity of mice treated with extracts. The results of present study shows that, chloroform extract (400 mg/kg and 600 mg/kg) and Ethanolic extracts (400 mg/kg) significantly decrease the immobility time of mice in FST and TST, whereas extracts did not show any significant effect on locomotor activity of the mice. The efficacy of extract was comparable to imipramine (15 mg/kg) and fluoxetine (20 mg/kg). This preliminary study demonstrated the antidepressant like effect of ethanolic and chloroform extract of Sargassum ilicifolium. However, additional research will be necessary to investigate the mechanism underlying this antidepressant-like effect.