The antidiabetic effects of Ethyl acetate (Et Ac), Petroleum-ether (Pet ether), and Chloroform fractions from methanolic extract of the seeds of Entada phaseoloides were investigated in alloxan induced diabetic mice (AIDM). The effect of these fractions (200 mg/kg body weight ip) was observed on fasting blood glucose (FBG) level and active fraction was further investigated for its dose dependent activity (250 and 350 mg/kg bw) on fasting blood glucose level and also on total cholesterol (TC), triglyceride (TG), serum glutamate oxaloacetate transaminases (SGOT) and serum glutamate pyruvate transaminases (SGPT) level in AIDM and found significant effects. The most significant reduction of FBG level of around 72.02% was observed for Et-Ac fraction in AIDM. A significant reduction (* p< 0.05) in serum TC and TG level of 53.00% and 57.25% respectively was also found for Et-Ac fraction of E. phaseoloides. The hypoglycemic and hypolipidemic activities were comparable to metformin HCl (150 mg/kg). In diabetic mice, SGOT and SGPT levels were significantly elevated that were further reduced after intraperitoneal administration of this fraction. These results indicate that Et-Ac fraction of E. phaseoloides have favorable effects in bringing down the severity of diabetes together with hepatoprotectivity. INTRODUCTION: Diabetes is a chronic metabolic disorder that is characterized by either the insufficient production or the lack of response to a key regulatory hor oe of the ody s eta olis, i suli. Dia etes is divided into two major categories: Type 1 diabetes (insulin-dependent diabetes mellitus or IDDM) and type 2 diabetes (non-insulin dependent diabetes mellitus or NIDDM). Type-1 diabetes, the cause is an absolute deficiency of insulin secretion and the cause of type-2 diabetes is a combination of resistance to insulin action and an inadequate compensatory insulinsecretory response 1. The overall prevalence of diabetes is approximately 10 percent of the population, of which 90 percent is type 2. There are estimated 246 million people worldwide sufferings from diabetes 2. In the United States, diabetes is the sixth leading cause of death 3. It is predicted that by 2030, India, China and the United States will have the largest number of people with diabetes 4.

The increasing worldwide incidence of diabetes mellitus in adults constitutes a significant impact on the health, quality of life, and life expectancy of patients, as well as on the global public health care system. The long term manifestation of this disease can result in the development of vascular disorders such as retinopathy, nephropathy, neuropathy, and angiopathy 5. Sedentary lifestyle, degree of obesity, changes in food consumption, ageing, and other concomitant medical conditions has been implicated in