Antifungal activity of anthraquinone derivatives from Rheum emodi
SK Agarwal, SS Singh, S Verma, S Kumar - Journal of ethnopharmacology, 2000 - Elsevier
SK Agarwal, SS Singh, S Verma, S Kumar
Journal of ethnopharmacology, 2000•Elsevier… emodi rhizomes. A bioassay guided isolation, characterisation and evaluation of their
methanolic extracts exhibited antifungal activities which resulted in four anthraquinone
derivatives (1–4) as active components. … The methanolic extract exhibited potent
antifungal activities in our primary screening programme. Chromatographic purification of
the methanol extract on silica gel produced rhein (1), physcion (2), aloe-emodin (3) and
chrysophanol (4). Their identities were established by comparing the mp, IR, 1 H NMR and …
methanolic extracts exhibited antifungal activities which resulted in four anthraquinone
derivatives (1–4) as active components. … The methanolic extract exhibited potent
antifungal activities in our primary screening programme. Chromatographic purification of
the methanol extract on silica gel produced rhein (1), physcion (2), aloe-emodin (3) and
chrysophanol (4). Their identities were established by comparing the mp, IR, 1 H NMR and …
Rhein, physcion, aloe-emodin and chrysophanol isolated from Rheum emodi rhizomes exhibited antifungal activity against Candida albicans, Cryptococcus neoformans, Trichophyton mentagrophytes and Aspergillus fumigatus (MIC 25–250 μg/ml).
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