Antinociceptive Activity of Aerial Parts of Polygonatum verticillatum: Attenuation of Both Peripheral and Central Pain Mediators
Polygonatum verticillatum All. is used traditionally as an analgesic and plant diuretic. The
methanol extract of aerial parts of Polygonatum verticillatum (PA) was assessed in various
experimental paradigms. The pain threshold in the form of abdominal constriction induced
by acetic acid was significantly (p< 0.01) inhibited by PA at test doses (50, 100 and 200
mg/kg). In the formalin test, PA elicited a significant (p< 0.01) analgesic activity in both
phases and strongly attenuated the formalin‐induced flinching behaviour. The hot plate test …
methanol extract of aerial parts of Polygonatum verticillatum (PA) was assessed in various
experimental paradigms. The pain threshold in the form of abdominal constriction induced
by acetic acid was significantly (p< 0.01) inhibited by PA at test doses (50, 100 and 200
mg/kg). In the formalin test, PA elicited a significant (p< 0.01) analgesic activity in both
phases and strongly attenuated the formalin‐induced flinching behaviour. The hot plate test …
Antinociceptive activity of aerial parts of Polygonatum verticillatum: attenuation of both peripheral and central pain mediators.
HK Haroon Khan, MS Muhammad Saeed… - 2011 - cabidigitallibrary.org
Polygonatum verticillatum All. is used traditionally as an analgesic and plant diuretic. The
methanol extract of aerial parts of Polygonatum verticillatum (PA) was assessed in various
experimental paradigms. The pain threshold in the form of abdominal constriction induced
by acetic acid was significantly (p< 0.01) inhibited by PA at test doses (50, 100 and 200
mg/kg). In the formalin test, PA elicited a significant (p< 0.01) analgesic activity in both
phases and strongly attenuated the formalin-induced flinching behaviour. The hot plate test …
methanol extract of aerial parts of Polygonatum verticillatum (PA) was assessed in various
experimental paradigms. The pain threshold in the form of abdominal constriction induced
by acetic acid was significantly (p< 0.01) inhibited by PA at test doses (50, 100 and 200
mg/kg). In the formalin test, PA elicited a significant (p< 0.01) analgesic activity in both
phases and strongly attenuated the formalin-induced flinching behaviour. The hot plate test …
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