BACKGROUND/PURPOSE: Hypoxia and ischemia appear to play an important role in the
pathogenesis of necrotizing enterocolitis (NEC), which may be related to oxygen-derived
free radical formation. This study was designed to evaluate the role of oxidative stress and
potentially beneficial effects of N-acetylcysteine (NAC) in a neonatal rat model of NEC.
METHODS: Thirty Wistar albino rat pups were randomly divided into 3 groups: group 1,
control; group 2, NEC and saline; and group 3, NEC and NAC treatment. Necrotizing …

Background and Aim Hypoxia and ischemia appear to play an important role in the
pathogenesis of necrotizing enterocolitis (NEC) which is related to oxygen-derived free
radical formation. This study was designed to evaluate the role of oxidative stress and
potentially beneficial effects of N-acetylcysteine (NAC) in a neonatal rat model of NEC.
Methods Thirty Wistar albino rat pups were randomly divided into 3 groups: group 1, control;
group 2, NEC and saline; group 3, NEC and NAC treatment. NEC was induced by …