Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious
antipsychotics, the relationship between its functional connectivity and symptomatic
reduction remains unknown. Objective To explore the longitudinal effect of treatment with
second-generation antipsychotics on functional connectivity of the striatum during the resting
state in patients experiencing a first episode of psychosis. Design, Setting, and Participants …