Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
Introduction Apathy adversely affects prognosis and survival of patients with frontotemporal
dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is
associated with cognitive decline and brain atrophy. Methods Presymptomatic carriers of
MAPT, GRN or C9orf72 mutations (N= 304), and relatives without mutations (N= 296)
underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal
changes in apathy, cognition, gray matter volumes, and their relationships were analyzed …
dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is
associated with cognitive decline and brain atrophy. Methods Presymptomatic carriers of
MAPT, GRN or C9orf72 mutations (N= 304), and relatives without mutations (N= 296)
underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal
changes in apathy, cognition, gray matter volumes, and their relationships were analyzed …
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