Arginase therapy combines effectively with immune checkpoint blockade or agonist anti-OX40 immunotherapy to control tumor growth
Metabolic dysregulation is a hallmark of cancer. Many tumors exhibit auxotrophy for various
amino acids, such as arginine, because they are unable to meet the demand for these
amino acids through endogenous production. This vulnerability can be exploited by
employing therapeutic strategies that deplete systemic arginine in order to limit the growth
and survival of arginine auxotrophic tumors. Pegzilarginase, a human arginase-1 enzyme
engineered to have superior stability and enzymatic activity relative to the native human …
amino acids, such as arginine, because they are unable to meet the demand for these
amino acids through endogenous production. This vulnerability can be exploited by
employing therapeutic strategies that deplete systemic arginine in order to limit the growth
and survival of arginine auxotrophic tumors. Pegzilarginase, a human arginase-1 enzyme
engineered to have superior stability and enzymatic activity relative to the native human …
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