Artemisinin triggers a G1 cell cycle arrest of human Ishikawa endometrial cancer cells and inhibits cyclin-dependent kinase-4 promoter activity and expression by …
KQ Tran, AS Tin, GL Firestone - Anti-cancer drugs, 2014 - journals.lww.com
Relatively little is known about the antiproliferative effects of artemisinin, a naturally
occurring antimalarial compound from Artemisia annua, or sweet wormwood, in human
endometrial cancer cells. Artemisinin induced a G1 cell cycle arrest in cultured human
Ishikawa endometrial cancer cells and downregulated cyclin-dependent kinase-2 (CDK2)
and CDK4 transcript and protein levels. Analysis of CDK4 promoter-luciferase reporter
constructs showed that the artemisinin ablation of CDK4 gene expression was accounted for …
occurring antimalarial compound from Artemisia annua, or sweet wormwood, in human
endometrial cancer cells. Artemisinin induced a G1 cell cycle arrest in cultured human
Ishikawa endometrial cancer cells and downregulated cyclin-dependent kinase-2 (CDK2)
and CDK4 transcript and protein levels. Analysis of CDK4 promoter-luciferase reporter
constructs showed that the artemisinin ablation of CDK4 gene expression was accounted for …
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