Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice

S Ichikawa, T Gohda, M Murakoshi, Z Li… - FEBS Open …, 2020 - Wiley Online Library
Diabetic kidney disease (DKD) is among the most common and serious complications of
both type 1 and type 2 diabetes. In this study, we used KK/Ta‐Ins2Akita (KK‐Akita) mice as a
model of DKD and KK/Ta (KK) mice as controls to identify novel factors related to the
development/progression of DKD. Capillary electrophoresis coupled with mass spectrometry
analysis revealed that circulating Asp (l‐aspartic acid) levels in diabetic KK‐Akita mice tend
to be lower than those in control KK mice. Therefore, we evaluated the effect of Asp …

Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice

市川沙紀, イチカワサキ - 2019 - jair.repo.nii.ac.jp
Diabetic kidney disease (DKD) is among the most common and serious complications of
both type 1 and type 2 diabetes. In this study, we used KK/Ta-Ins2Akita (KK-Akita) mice as a
model of DKD and KK/Ta (KK) mice as controls to identify novel factors related to the
development/progression of DKD. Capillary electrophoresis coupled with mass spectrometry
analysis revealed that circulating Asp (L-aspartic acid) levels in diabetic KK-Akita mice tend
to be lower than those in control KK mice. Therefore, we evaluated the effect of Asp …
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