Aspergillus fumigatus acetate utilization impacts virulence traits and pathogenicity
Aspergillus fumigatus is a major opportunistic fungal pathogen of immunocompromised and
immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use
host carbon sources, such as acetate, present in the body fluids and peripheral tissues.
However, utilization of acetate as a carbon source by fungi in the context of infection has not
been investigated. This work shows that acetate is metabolized via different pathways in A.
fumigatus and that acetate utilization is under the regulatory control of a transcription factor …
immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use
host carbon sources, such as acetate, present in the body fluids and peripheral tissues.
However, utilization of acetate as a carbon source by fungi in the context of infection has not
been investigated. This work shows that acetate is metabolized via different pathways in A.
fumigatus and that acetate utilization is under the regulatory control of a transcription factor …
[PDF][PDF] Aspergillus fumigatus acetate utilization impacts virulence traits and pathogenicity. mBio 12 (4): e0168221
Aspergillus fumigatus is a major opportunistic fungal pathogen of immunocompromised and
immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use
host carbon sources, such as acetate, present in the body fluids and peripheral tissues.
However, utilization of acetate as a carbon source by fungi in the context of infection has not
been investigated. This work shows that acetate is metabolized via different pathways in A.
fumigatus and that acetate utilization is under the regulatory control of a transcription factor …
immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use
host carbon sources, such as acetate, present in the body fluids and peripheral tissues.
However, utilization of acetate as a carbon source by fungi in the context of infection has not
been investigated. This work shows that acetate is metabolized via different pathways in A.
fumigatus and that acetate utilization is under the regulatory control of a transcription factor …
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