Pathologists are highly skilled at the evaluation of adrenal neoplasms. Occasional
adrenocortical tumors can be diagnostically challenging and supplementary tools can assist
in these cases. Histologic and molecular studies support a model that includes 2 broad
classes of adrenocortical carcinoma with distinct somatic genetic alterations and clinical
outcomes. Pathologists should endeavor to grade adrenocortical carcinomas to assign each
case into one of these 2 classes. Mitotic grading by mitotic counting and Ki-67 …