Groundwater (GW) is an important source of water in many countries around the world. Among them, Egypt which depends mainly on ground water as a major source of water through its desert regions, specifically in the Western region of Nile Delta. However, increasingly deterioration of GW quality threatens its uses strategies. DRASTIC approach was used to determine vulnerability zones in the Western Nile Delta region. First, maps of five DRASTIC models were compared and analyzed using GIS-ArcView, including DRASTIC, Pesticide DRASTIC, modified DRASTIC, Pesticide DRASTIC-LU and Susceptibility Index (SI). Second, validation for the vulnerability models were performed by comparing Nitrate measurements. Finally, a sensitivity analysis was performed to assess DRASTICS’s performance and to identify most critical hydrological parameters for vulnerability assessment. The DRASTIC, Pesticide DRASTIC-LU and SI maps ranked 25% of the Western Nile Delta region as very highly vulnerable. While the modified DRASTIC model classified 31% of the study area as very highly vulnerable. Furthermore, the sensitivity analysis showed that the vadose zone is the most important parameter for all DRASTIC models. Additionally, the validation results showed that the SI model experienced the highest correlation with Nitrate (0.66). The vulnerability maps proved its reliability as an important tool for planning of land use and effective management of GW resource Western Nile Delta region and any similar regions.