Importance In most patients, a prodromal period precedes the onset of schizophrenia.
Although clinical criteria for identifying the psychosis risk syndrome (PRS) show promising
predictive validity, assessment of neurophysiologic abnormalities in at-risk individuals may
improve clinical prediction and clarify the pathogenesis of schizophrenia. Objective To
determine whether P300 event-related potential amplitude, which is deficient in
schizophrenia, is reduced in the PRS and associated with clinical outcomes. Design …