Background Rheumatoid arthritis (RA) is a common autoimmune disease with a complex
genetic background. The genes encoding protein tyrosine phosphatase non-receptor type
22 (PTPN22) and signal transducer and activator of transcription 4 (STAT4) have been
reported to be associated with RA in several ethnic populations. Objectives This work aims
to assess the association between PTPN22 rs2476601 and STAT4 rs7574865
polymorphisms with RA susceptibility through an updated meta-analysis of available case …

Aim: The aim of the present study was to replicate the association of five risk gene
polymorphisms (PTPN22--rs2476601, STAT4-rs7574865, 6q23-rs6927172, IRF5-
rs2004640 and TRAF1/C5-rs10818488) with RA in a specific population of the Western
Algeria. Material and methods: The study group comprised 110 patients with RA and 197
ethnically matched heal thy control subjects. All polymorphisms were genotyped using
predesigned TaqMan® assays. Allele and genotype frequencies in patients and control …