Asthma is a risk factor for respiratory exacerbations without increased rate of lung function decline: five-year follow-up in adult smokers from the COPDGene study
Background Previous investigations in adult smokers from the COPDGene Study have
shown that early-life respiratory disease is associated with reduced lung function, COPD,
and airway thickening. Using 5-year follow-up data, we assessed disease progression in
subjects who had experienced early-life respiratory disease. We hypothesized that there are
alternative pathways to reaching reduced FEV 1 and that subjects who had childhood
pneumonia, childhood asthma, or asthma-COPD overlap (ACO) would have less lung …
shown that early-life respiratory disease is associated with reduced lung function, COPD,
and airway thickening. Using 5-year follow-up data, we assessed disease progression in
subjects who had experienced early-life respiratory disease. We hypothesized that there are
alternative pathways to reaching reduced FEV 1 and that subjects who had childhood
pneumonia, childhood asthma, or asthma-COPD overlap (ACO) would have less lung …
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