Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund's Adjuvant‐Induced Arthritis Rats
L Dong, J Zhu, H Du, H Nong, X He… - Evidence‐Based …, 2017 - Wiley Online Library
Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb.(with
red cross‐section) grown in Guizhou Province, China. We accessed its effect and potential
mechanism on attenuation of the inflammatory response in CFA‐induced AA rats. Our
results showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in
the hind paw of AA rats. Accordingly, astilbin exhibited remarkable inhibitory effects on TNF‐
α, IL‐1β, and IL‐6 mRNA expression. Significant decrease of serum cytokine levels of TNF …
red cross‐section) grown in Guizhou Province, China. We accessed its effect and potential
mechanism on attenuation of the inflammatory response in CFA‐induced AA rats. Our
results showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in
the hind paw of AA rats. Accordingly, astilbin exhibited remarkable inhibitory effects on TNF‐
α, IL‐1β, and IL‐6 mRNA expression. Significant decrease of serum cytokine levels of TNF …
Astilbin from Smilax glabra Roxb. attenuates inflammatory responses in complete Freund's adjuvant-induced arthritis rats.
DLS Dong LiSha, ZJQ Zhu JinQiu, DHZ Du HongZhi… - 2017 - cabidigitallibrary.org
Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb.(with
red cross-section) grown in Guizhou Province, China. We accessed its effect and potential
mechanism on attenuation of the inflammatory response in CFA-induced AA rats. Our results
showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in the
hind paw of AA rats. Accordingly, astilbin exhibited remarkable inhibitory effects on TNF-α, IL-
1β, and IL-6 mRNA expression. Significant decrease of serum cytokine levels of TNF-α, IL …
red cross-section) grown in Guizhou Province, China. We accessed its effect and potential
mechanism on attenuation of the inflammatory response in CFA-induced AA rats. Our results
showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in the
hind paw of AA rats. Accordingly, astilbin exhibited remarkable inhibitory effects on TNF-α, IL-
1β, and IL-6 mRNA expression. Significant decrease of serum cytokine levels of TNF-α, IL …
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