Astragaloside IV alleviates the experimental DSS-induced colitis by remodeling macrophage polarization through STAT signaling
L Tian, JL Zhao, JQ Kang, S Guo, N Zhang… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal
inflammation, which currently lacks safe and effective medicine. Some previous studies
indicated that Astragaloside IV (AS-IV), a natural saponin extracted from the traditional
Chinese medicine herb Ligusticum chuanxiong, alleviates the experimental colitis symptoms
in vitro and in vivo. However, the mechanism of AS-IV on IBD remains unclear. Accumulating
evidence suggests that M2-polarized intestinal macrophages play a pivotal role in IBD …
inflammation, which currently lacks safe and effective medicine. Some previous studies
indicated that Astragaloside IV (AS-IV), a natural saponin extracted from the traditional
Chinese medicine herb Ligusticum chuanxiong, alleviates the experimental colitis symptoms
in vitro and in vivo. However, the mechanism of AS-IV on IBD remains unclear. Accumulating
evidence suggests that M2-polarized intestinal macrophages play a pivotal role in IBD …
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