Asymmetric transfer hydrogenation of benzaldehydes
A combined system of RuCl [(R, R)-YCH (C6H5) CH (C6H5) NH2](η6-arene)(Y=
NSO2C6H4-4-CH3 or O) and t-C4H9OK catalyzes the asymmetric transfer hydrogenation of
various benzaldehyde-1-d derivatives with 2-propanol to yield (R)-benzyl-1-d alcohols in
95− 99% ee and with> 99% isotopic purity. Reaction of benzaldehydes with a DCO2D-
triethylamine mixture and the R, R catalyst affords the S deuterated alcohols in 97− 99% ee.
NSO2C6H4-4-CH3 or O) and t-C4H9OK catalyzes the asymmetric transfer hydrogenation of
various benzaldehyde-1-d derivatives with 2-propanol to yield (R)-benzyl-1-d alcohols in
95− 99% ee and with> 99% isotopic purity. Reaction of benzaldehydes with a DCO2D-
triethylamine mixture and the R, R catalyst affords the S deuterated alcohols in 97− 99% ee.
A combined system of RuCl[(R,R)-YCH(C6H5)CH(C6H5)NH2](η6-arene) (Y = NSO2C6H4-4-CH3 or O) and t-C4H9OK catalyzes the asymmetric transfer hydrogenation of various benzaldehyde-1-d derivatives with 2-propanol to yield (R)-benzyl-1-d alcohols in 95−99% ee and with >99% isotopic purity. Reaction of benzaldehydes with a DCO2D-triethylamine mixture and the R,R catalyst affords the S deuterated alcohols in 97−99% ee.
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