Amphipathic peptides can cause biological membranes to leak either by dissolving their
lipid content via a detergent-like mechanism or by forming pores on the membrane surface.
These modes of membrane damage have been related to the toxicity of amyloid peptides
and to the activity of antimicrobial peptides. Here, we perform the first all-atom simulations in
which membrane-bound amphipathic peptides self-assemble into β-sheets that
subsequently either form stable pores inside the bilayer or drag lipids out of the membrane …

Amphipathic peptides can cause biological membranes to leak either by dissolving their
lipid content via a detergent-like mechanism or by forming pores on the membrane surface.
These modes of membrane damage have been related to the toxicity of amyloid peptides
and to the activity of antimicrobial peptides. Here, we will discuss all-atom simulations in
which membrane-bound amphipathic peptides self-assemble into beta-sheets that
subsequently either form stable pores inside the bilayer or drag lipids out of the membrane …