An original approach of macromolecular 'induced-fit'flexibility, namely the static modes, is
applied to shed light on some fundamental mechanisms impacting DNA conformations. We
first investigate a constrained nucleic acid of the D-CNA family, in which some backbone
torsional angles are conformationally restricted by a dioxaphosphorinane ring structure. We
take a special interest in α, β-D-CNA, in which α and β angles are restricted to the canonical
conformation. We used the static mode method to evaluate the impact of the insertion of …