[HTML][HTML] Atrial and brain natriuretic peptides: Hormones secreted from the heart

Y Nakagawa, T Nishikimi, K Kuwahara - Peptides, 2019 - Elsevier
The natriuretic peptide family consists of three biologically active peptides: atrial natriuretic
peptide (ANP), brain (or B-type) natriuretic peptide (BNP), and C-type natriuretic peptide
(CNP). Among these, ANP and BNP are secreted by the heart and act as cardiac hormones.
Both ANP and BNP preferentially bind to natriuretic peptide receptor-A (NPR-A or guanylyl
cyslase-A) and exert similar effects through increases in intracellular cyclic guanosine
monophosphate (cGMP) within target tissues. Expression and secretion of ANP and BNP …
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