Automated pipeline for purification, biophysical and x-ray analysis of biomacromolecular solutions
Scientific reports, 2015•nature.com
Small angle X-ray scattering (SAXS), an increasingly popular method for structural analysis
of biological macromolecules in solution, is often hampered by inherent sample
polydispersity. We developed an all-in-one system combining in-line sample component
separation with parallel biophysical and SAXS characterization of the separated
components. The system coupled to an automated data analysis pipeline provides a novel
tool to study difficult samples at the P12 synchrotron beamline (PETRA-3, EMBL/DESY …
of biological macromolecules in solution, is often hampered by inherent sample
polydispersity. We developed an all-in-one system combining in-line sample component
separation with parallel biophysical and SAXS characterization of the separated
components. The system coupled to an automated data analysis pipeline provides a novel
tool to study difficult samples at the P12 synchrotron beamline (PETRA-3, EMBL/DESY …
Abstract
Small angle X-ray scattering (SAXS), an increasingly popular method for structural analysis of biological macromolecules in solution, is often hampered by inherent sample polydispersity. We developed an all-in-one system combining in-line sample component separation with parallel biophysical and SAXS characterization of the separated components. The system coupled to an automated data analysis pipeline provides a novel tool to study difficult samples at the P12 synchrotron beamline (PETRA-3, EMBL/DESY, Hamburg).
nature.com
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