… Although both NDP52 and p62 are direct targets of TBK1 activity that promote selective
autophagy, our findings indicate that NDP52 and p62 may also promote autophagy of pTBK1 …

… -driven pancreatic tumorigenesis by increasing the TBK1 (TANK … Autophagy inhibitors put
PSCs in a quiescent state and … , thereby inhibiting inflammation and pancreatic tumor growth in …

… , through selective autophagy, … that TBK1 is involved in many cellular signaling pathways
that contribute to diverse pathologies. In this review the role of TBK1 in autophagic signaling, …

… pancreatic models, in which oncogenic KRAS drives disease similar to human pancreatic
cancer… to suppress autophagy and TBK1 is known to promote autophagy, one would argue that …

… , dysregulated TBK1 signaling has been linked to a variety of … by TBK1, including inflammation,
cell cycle, autophagy, energy … TBK1 and autophagy, whereby active TBK1 promotes basal …

… ……………2 TBK1 promotes autophagy during pathogen infection and oncogenic stress..4 …
TBK1 promotes pancreatic tumor cell motility, we stably re-expressed full-length human TBK1 …

… the treatment of inflammatory and autoimmune diseases.6, 7 TBK1-regulated autophagy has
an … This finding suggests the future utility of inhibition of TBK1-mediated autophagy in the …

… Dysregulated autophagy might promote the inflammatory response in the pancreas. We …
ATG5 deficiency in the pancreas also up-regulates TBK1, resulting in increased levels of type I …

… the RNF128/TBK1 axis as independent regulators of inflammation. Altogether, our work
highlights increased autophagic flux as a potential approach to reduce inflammation and defines …

… The normal level of autophagy can protect cells from environmental stimuli, but continued …
autophagy could lead to disease 35,36 . Previous studies have revealed that autophagy is …