[HTML][HTML] Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9
JM Goodwin, WE Dowdle, R DeJesus, Z Wang… - Cell reports, 2017 - cell.com
Iron is vital for many homeostatic processes, and its liberation from ferritin nanocages occurs
in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor
coactivator-4 (NCOA4) are targeted to lysosomes by a form of selective autophagy. By using
genome-scale functional screening, we identify an alternative lysosomal transport pathway
for ferritin that requires FIP200, ATG9A, VPS34, and TAX1BP1 but lacks involvement of the
ATG8 lipidation machinery that constitutes classical macroautophagy. TAX1BP1 binds …
in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor
coactivator-4 (NCOA4) are targeted to lysosomes by a form of selective autophagy. By using
genome-scale functional screening, we identify an alternative lysosomal transport pathway
for ferritin that requires FIP200, ATG9A, VPS34, and TAX1BP1 but lacks involvement of the
ATG8 lipidation machinery that constitutes classical macroautophagy. TAX1BP1 binds …
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