BDNF and NT‐3, but not NGF, Prevent Axotomy‐induced Death of Rat Corticospinal Neurons In Vivo
KM Giehl, W Tetzlaff - European journal of neuroscience, 1996 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 (NT‐3) have been identified
as survival factors for adult axotomized rat corticospinal neurons (CSN) in vivo. Axotomy of
corticospinal neurons at the level of the internal capsule induced death of 46% of the CSN
within the first week after axotomy. The surviving population of CSN displayed severe
atrophy with mean cross‐sectional area 49% of their unlesioned contralateral counterparts 7
days after axotomy. Using in situ hybridization to assess the expression of the receptors for …
as survival factors for adult axotomized rat corticospinal neurons (CSN) in vivo. Axotomy of
corticospinal neurons at the level of the internal capsule induced death of 46% of the CSN
within the first week after axotomy. The surviving population of CSN displayed severe
atrophy with mean cross‐sectional area 49% of their unlesioned contralateral counterparts 7
days after axotomy. Using in situ hybridization to assess the expression of the receptors for …
[PDF][PDF] BDNF and NT-3, but not NGF, Prevent Axotomy-induced Death of Rat Corticospinal Neurons In Vivo
W Tetzlaff - academia.edu
Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) have been identified as
survival factors for adult axotomized rat corticospinal neurons (CSN) in vivo. Axotomy of
corticospinal neurons at the level of the internal capsule induced death of 46% of the CSN
within the first week after axotomy. The surviving population of CSN displayed severe
atrophy with mean cross-sectional area 49% of their unlesioned contralateral counterparts 7
days after axotomy. Using zyxwvutsrqponmlkj in situ hybridization to assess the expression …
survival factors for adult axotomized rat corticospinal neurons (CSN) in vivo. Axotomy of
corticospinal neurons at the level of the internal capsule induced death of 46% of the CSN
within the first week after axotomy. The surviving population of CSN displayed severe
atrophy with mean cross-sectional area 49% of their unlesioned contralateral counterparts 7
days after axotomy. Using zyxwvutsrqponmlkj in situ hybridization to assess the expression …