Back to the future: application of contemporary technology to long-standing questions about the clinical relevance of human leukocyte antigen-specific alloantibodies …
CJ Taylor, V Kosmoliaptsis, DM Summers… - Human immunology, 2009 - Elsevier
Luminex technology allows the accurate identification of human leukocyte antigen (HLA)
class I and class II-specific antibodies at levels below the threshold detectable by either
conventional complement-dependent lymphocytotoxicity or flow cytometry. The technology
enables the analysis of complex antibody profiles in sensitized patients and gives improved
definition of acceptable and unacceptable HLA specificities to guide donor kidney allocation.
This helps to facilitate virtual cross-matching and avoid inappropriate shipping of kidneys for …
class I and class II-specific antibodies at levels below the threshold detectable by either
conventional complement-dependent lymphocytotoxicity or flow cytometry. The technology
enables the analysis of complex antibody profiles in sensitized patients and gives improved
definition of acceptable and unacceptable HLA specificities to guide donor kidney allocation.
This helps to facilitate virtual cross-matching and avoid inappropriate shipping of kidneys for …
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