Bacterial origin of a mitochondrial outer membrane protein translocase: new perspectives from comparative single channel electrophysiology*♦
Mitochondria are of bacterial ancestry and have to import most of their proteins from the
cytosol. This process is mediated by Tom40, an essential protein that forms the protein-
translocating pore in the outer mitochondrial membrane. Tom40 is conserved in virtually all
eukaryotes, but its evolutionary origin is unclear because bacterial orthologues have not
been identified so far. Recently, it was shown that the parasitic protozoon Trypanosoma
brucei lacks a conventional Tom40 and instead employs the archaic translocase of the outer …
cytosol. This process is mediated by Tom40, an essential protein that forms the protein-
translocating pore in the outer mitochondrial membrane. Tom40 is conserved in virtually all
eukaryotes, but its evolutionary origin is unclear because bacterial orthologues have not
been identified so far. Recently, it was shown that the parasitic protozoon Trypanosoma
brucei lacks a conventional Tom40 and instead employs the archaic translocase of the outer …
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