Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice
P Sportoletti, D Sorcini, AG Guzman, JM Reyes… - Leukemia, 2021 - nature.com
Recurrent loss-of-function mutations of BCL6 co-repressor (BCOR) gene are found in about
4% of AML patients with normal karyotype and are associated with DNMT3a mutations and
poor prognosis. Therefore, new anti-leukemia treatments and mouse models are needed for
this combinatorial AML genotype. For this purpose, we first generated a Bcor−/− knockout
mouse model characterized by impaired erythroid development (macrocytosis and anemia)
and enhanced thrombopoiesis, which are both features of myelodysplasia/myeloproliferative …
4% of AML patients with normal karyotype and are associated with DNMT3a mutations and
poor prognosis. Therefore, new anti-leukemia treatments and mouse models are needed for
this combinatorial AML genotype. For this purpose, we first generated a Bcor−/− knockout
mouse model characterized by impaired erythroid development (macrocytosis and anemia)
and enhanced thrombopoiesis, which are both features of myelodysplasia/myeloproliferative …
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