Background: Recent clinical and preclinical studies have suggested that deep brain
stimulation (DBS) can be used as a tool to enhance cognitive functions. The aim of the
present study was to investigate the impact of DBS at three separate targets in the Papez
circuit, including the anterior nucleus of thalamus (ANT), the entorhinal cortex (EC), and the
fornix (FX), on cognitive behaviors in an Alzheimer's disease (AD) rat model. Methods: Forty-
eight rats were subjected to an intrahippocampal injection of amyloid peptides 1-42 to …