The Technology Acceptance Model (TAM) is a model used to predict user acceptance of information systems based on perceived usefulness and perceived ease of use. If the user sees the benefits and ease of using the information system, it will cause the user to accept it. This study examines IT system quality and perceived usefulness to reuse online learning applications. This research analyses the measurement of perceptions of the quality of the IT system used by respondents in the scope of online learning. We operate a survey method; the respondents in this research were students and teaching staff users of online learning applications. Respondents, most of whom are students in Sumatra, are interested or intend to reuse online learning applications if there is a good information quality factor and more benefits from online applications. The perceived usefulness construct plays a full role in mediating the relationship between information quality and intention to reuse online learning applications.