In order to investigate the effect of bile acids on gastrointestinal inflammations, bile duct
ligated rats (BDL) were treated with GCA (25 mM/ml, oral or colonic) or saline 1 h before
ethanol challenge and twice daily for 3 days in the ileitis group, while GCA was given twice
daily for 3 days in the colitis group. BDL reduced the macroscopic and microscopic damage
scores in the ileitis group compared to sham operated group, while it had no significant
effect on ulcer or colitis groups. However, GCA given in BDL group reduced the ulcer index …

Beneficial effects of glycocholic acid (GCA) on gut mucosal damage in bile duct ligated (BDL)
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operation purposes. … Beneficial effects of glycocholic acid (GCA) on gut mucosal damage …