Background Berberine is known to improve glucose and lipid metabolism disorders, but it
poorly absorbed into the blood stream from the gut. Therefore, the exact underlying
mechanism for berberine is still unknown. In this study, we investigated the effect of
berberine on glucose metabolism in diabetic rats and tested the hypothesis that berberine
acts directly in the terminal ileums. Methods Rats were divided into a control group, diabetic
group (DM), low dose of berberine group (BerL) and high dose of berberine group (BerH) …

Background: Berberine is known to improve glucose and lipid metabolism disorders, but it
poorly absorbed into the blood stream from the gut. Therefore, the exact underlying
mechanism for berberine is still unknown. In this study, we investigated the effect of
berberine on glucose metabolism in diabetic rats and tested the hypothesis that berberine
acts directly in the terminal ileums. Methods: Rats were divided into a control group, diabetic
group (DM), low dose of berberine group (BerL) and high dose of berberine group (BerH) …