This work reports a high power, stable, completely Pt-free anion exchange membrane fuel cell (AEMFC) comprised of highly active catalysts–Pd-CeO 2/C at the anode and PdCu/C alloy at the cathode for the hydrogen oxidation and oxygen reduction reactions, respectively. The resulting AEMFC shows outstanding performance, reaching a peak power density of 1 W cm− 2, twice the value of the best performance for Pt-free cells reported in the literature to date. The AEMFC also shows a low voltage degradation rate when operated continuously for more than 100 h at a constant 0.5 A cm− 2, with a voltage degradation rate of only 2.5 mV h-1, which is excellent when compared to nearly all of the AEMFCs reported in the literature to date. This combination of high performance and high stability in the absence of Pt-based catalysts represents a significant landmark in the progress of the AEMFC technology.