Over the past three decades, Pd-catalyzed cross-coupling reactions have become a
mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines
have shown wide utility in forming C–N bonds under mild reaction conditions. This work
summarizes a variety of C–N cross-coupling reactions using biaryl monophosphines as
supporting ligands, with the goal of directing synthetic chemists towards the ligands and
conditions best suited for a particular coupling. Prelude When I learned that I had received …